Protak Scientific and Netsteril Partner To Bring Revolutionary Alternative To Biological Indicators To The Spanish Pharmaceutical and Medical Sectors.
Protak Scientific, the UK company leading the introduction of a revolutionary new science in decontamination validation worldwide, the Enzyme Indicator, has partnered with Netsteril to bring the technology to Spain.
Enzyme Indicators are a new, viable and instant alternative to the current biological indicators used in decontamination validation. The 7-day waiting time to get the results of the Biological Indicators (BI) has come to an end. These new biochemical indicators allow results of validation of vapour decontamination with hydrogen peroxide (VH2O2) to be obtained in an instantaneous and quantifiable way. It is a disruptive technology developed by Public Health England (PHE), an executive agency of the United Kingdom’s Department of Health (UK DoH). Protak Scientific is the exclusive licensee of the technology and has appointed Netsteril as the exclusive distributor in Spain.
The Enzyme Indicator is based on Adenylate Kinase, an enzyme whose presence and activity can be rapidly measured by luminescence assays. This enzyme, unlike many proteins, is very thermostable and resistant to oxidizing agents. It has a very predictable biphasic inactivation profile. These characteristics make it suitable for monitoring and quantification of oxidation decontamination processes such as VH2O2. Indicators with thermostable Adenylate Kinase (tAK), once processed, are used to catalyse a biochemical reaction with Luciferin / Luciferase. Such a reaction produces bioluminescence instantaneously. The individual photons of light produced by this reaction are recorded with a special Lunometer and an accurate measure of the degree of inactivation of the tAK indicator is achieved. At the same time, it allows the user to directly quantify and extrapolate the logarithmic reduction achieved with the decontamination process.
Phillip Godden, CEO, Protak Scientific explains, “The Enzyme Indicator is a surrogate of the Biological Indicator (Geobacillus Stearothermofillus). In order to check their reliability, they can initially be combined with biological indicators, both for cycle development and for validation. Once validation is concluded and its reliability verified, this new technology offers two great advantages – it gives quantitative results, for example a degree of reduction Logarithmic i.e. Log 6.55 reduction and gives them instantaneously – amazingly in less than 3 seconds. The enzymatic indicators, together with the cycle parameters of the VH2O2 generator equipment, provide an immediate and quantitative proof that the decontamination cycle has achieved the expected results. And this, can save lives.”