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Enzymatic indicators are called to be the alternative to biological indicators to validate biodecontamination processes by vaporized hydrogen peroxide VH2O2.
In fact, although Bacillus stearothermophilus is used in the pharmaceutical industry as the reference biological indicator for ad-hoc validations, it is not exactly the most resistant spore to hydrogen peroxide In fact, the Bacillus stearothermophilus spore, used in the pharmaceutical industry as a biological reference indicator for ad-hoc validations, is not exactly the most resistant to hydrogen peroxide. It has become the standard because it was already marketed for steam sterilization, making it readily available in different populations. In addition, it is not pathogenic, it grows relatively quickly (in 24-48 hours it can give indications, although it is officially necessary to wait 7 days) and it is incubated at 55⁰C (which helps to rule out false positives). However, it has some limitations and being aware of this, it is essential….